public class MvcApplication : System.Web.HttpApplication
    {
        private static IConnection connection;
        private static IModel channel;

        protected void Application_Start()
        {
      .....
            this.SubscribeRabbitMq();
        }

        protected void Application_End()
        {
            channel.Close(200, "Асталависта!");
            connection.Close();
        }

        private void SubscribeRabbitMq()
        {
            var factory = new ConnectionFactory() { HostName = "localhost" };
            connection = factory.CreateConnection();
            channel = connection.CreateModel();
            channel.QueueDeclare(queue: "r2d2", durable: false, exclusive: false, autoDelete: false, arguments: null);

            var consumer = new EventingBasicConsumer(channel);
            consumer.Received += (model, ea) =>
            {
                var body = ea.Body;
                var message = Encoding.UTF8.GetString(body);
                // Display message with signalr
                var context = GlobalHost.ConnectionManager.GetHubContext<SomeHub>();
                 context.Clients.All.Notification(body)
            };
            channel.BasicConsume(queue: "hello", noAck: true, consumer: consumer);
        }
    }