var dt = new DataTable();
            dt.Columns.AddRange(new[] { new DataColumn("ID", typeof(int)), new DataColumn("FAM", typeof(string)), new DataColumn("NAM", typeof(string)) });
            dt.Rows.Add(1, "Петров", "Иван");
            dt.Rows.Add(2, "Иванов", "Сергей");
            dt.Rows.Add(3, "Сидоров", "Максим");
            dt.Rows.Add(4, "Павлов", "Алексей");

            var arr = new[] { "Петров", "Егоров", "Алексеев", "Павлов", "Макаров" };

            var other = from d in dt.AsEnumerable()
                        where !arr.Contains(d.Field<string>("FAM"))
                        select d;

Dim other = From d In dt.AsEnumerable()
                    Where Not arr.Contains(d.Field(Of String)("FAM"))
                    Select d