routes.MapRoute( name: "Default", url: "{controller}/{action}/{id}", defaults: new { controller = "Home", action = "Index", id = UrlParameter.Optional } );
RouteTable.Routes.Add(new ServiceRoute("files", new WebServiceHostFactory(), typeof(UploadManager)));

[WebInvoke(UriTemplate = "UploadFile/{fileName}/{description}", Method = "POST")]
public void UploadFile(string fileName, string description, Stream fileContents)
{
}

[WebInvoke(UriTemplate = "UploadFile2/{fileName}", Method = "POST")]
public void UploadFile2(string fileName, Stream fileContents)
{
}

http://localhost/files/UploadFile/somefile.txt/somedesc

http://localhost/files/UploadFile2/somefile.txt